The World Health Organization has revised its guidelines on reducing the risk of cognitive decline and dementia, underscoring the importance of preventive strategies throughout the lifespan.
Dr. Howard Chertkow, scientific director of a Toronto brain‑health centre, stresses that education, lifestyle changes, and motivation programs are essential for preserving brain function as people age.
World Brain Day on July 22 aims to raise public awareness of neurological disorders, highlighting that roughly 747,000 Canadians are currently living with Alzheimer’s disease or other forms of dementia.
Although no cure exists, recent research suggests that up to 45 % of dementia risk could be prevented or delayed through targeted interventions.
Regular physical activity tops the list of protective measures; achieving 150 minutes of vigorous exercise each week can lower the risk of heart disease, stroke, depression, and dementia.
Additional lifestyle adjustments—including a balanced diet, regular social interaction, mentally stimulating activities, avoidance of harmful substances, and treatment of sleep‑related conditions—contribute to overall brain health.
Maintaining oral hygiene also plays a role; daily flossing reduces bacterial load in the gums, which may help protect the brain from inflammatory processes.
The drug lecanemab, which targets amyloid‑beta plaques, received approval after an initial rejection and carries a treatment cost of $40,000‑$50,000 for a 12‑ to 18‑month course, without coverage under the provincial health plan.
Clinical data indicate that lecanemab can slow cognitive decline by approximately 30 % in individuals with mild Alzheimer’s, offering a modest benefit rather than a cure.
Emerging research presented at an international conference includes blood‑based diagnostic tests, anti‑inflammatory medications, and investigations into existing drugs such as sildenafil and tadalafil for potential neuroprotective effects.
These candidates must still navigate rigorous, time‑intensive trials before reaching the market, and experts caution that a definitive breakthrough in Alzheimer’s treatment remains years away.
