Police officers are currently on scene as traffic has been halted on the M67 following a serious incident.
The motorway will remain closed in both directions for the majority of the day, and drivers are being urged to seek alternative routes.
Authorities have expressed regret for the disruption and asked motorists to exercise patience while investigations continue.
In addition, the A628 Woodhead Pass has been closed in both directions between Hollingworth and the A616 Flouch roundabout due to a serious road traffic collision.
National Highways confirmed the closure, and police remain present at the site to manage the situation.
Motorists are advised to plan their journeys accordingly and follow any further instructions from law enforcement.
